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Medications That Worsen RLS (Antihistamines, SSRIs, etc.)

Published: 11/19/2025Reading time: 4 min readBy: Dr. Sarah Thompson, Pain Management Specialist
Vibration-therapypain-managementUK-healthcare

Understanding Medications That Worsen Restless Leg Syndrome (RLS) in the UK

Restless Leg Syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs, often accompanied by uncomfortable sensations. While the exact cause of RLS remains unclear, it is known that certain medications can exacerbate the symptoms. For UK patients dealing with chronic pain and RLS, understanding these medications and exploring alternative treatments is crucial. This article delves into the medications that can worsen RLS, UK-specific healthcare pathways, and effective management strategies, including the use of shockwave therapy and Therapulse devices.

Medications That Can Worsen RLS

Antihistamines

Antihistamines, commonly used to treat allergies and colds, can intensify RLS symptoms. Medications like diphenhydramine, found in many over-the-counter sleep aids, can contribute to increased restlessness. For patients in the UK, it is advisable to consult with a GP before using antihistamines if you have RLS. Consider alternatives like saline nasal sprays or non-sedating antihistamines such as loratadine, which may have a lesser impact on RLS symptoms.

Selective Serotonin Reuptake Inhibitors (SSRIs)

SSRIs, often prescribed for depression and anxiety, can also worsen RLS. Medications such as sertraline and fluoxetine are known to exacerbate symptoms in some patients. If you are experiencing increased RLS symptoms while on SSRIs, discuss with your GP the possibility of switching to an alternative antidepressant, like bupropion, which has a lesser impact on RLS.

Other Medications

  • Antipsychotics: Medications like olanzapine can increase RLS symptoms. Consult your GP for alternative treatments.
  • Tricyclic Antidepressants: These, including amitriptyline, may worsen RLS. Alternatives should be discussed with your GP.
  • Calcium Channel Blockers: Used for high blood pressure, these can also affect RLS. Discuss with your GP if you notice worsening symptoms.

Practical Steps to Mitigate Medication-Induced RLS

Consultation with Healthcare Providers

Regular consultations with your GP are crucial for managing RLS, especially when medications are involved. Schedule regular check-ups to discuss any changes in symptoms or side effects. Your GP can provide referrals to specialists, such as neurologists, if necessary.

Exploring Alternative Treatments

For those experiencing medication-induced RLS, exploring alternative therapies can be beneficial. Shockwave therapy and Therapulse devices are emerging as effective treatments in the UK.

  • Shockwave Therapy: This non-invasive treatment uses sound waves to improve blood circulation and reduce nerve irritation. Available through private clinics, costs can range from £80 to £200 per session.
  • Therapulse Devices: These wearable devices use pulsed electromagnetic fields to stimulate blood flow and reduce discomfort. Available online, devices typically cost between £100 and £300.

Common Mistakes and How to Avoid Them

Self-Medication

Avoid self-medicating with over-the-counter drugs without consulting a GP, as this can worsen RLS symptoms. Always seek professional advice before starting or stopping any medication.

Ignoring Symptoms

Failing to address worsening RLS symptoms can lead to increased discomfort and disrupted sleep. Keep a symptom diary to track changes and discuss them with your GP during appointments.

Long-Term Strategies and Implementation Guidance

Lifestyle Modifications

Incorporating lifestyle changes can significantly improve RLS symptoms. Regular exercise, a balanced diet rich in iron, and maintaining a consistent sleep schedule are beneficial. Consider joining local support groups, such as those offered by the RLS-UK foundation, for additional tips and community support.

Regular Monitoring

Regularly monitor your condition and treatment efficacy. Use mobile apps to track symptoms and medication side effects. This data can be shared with your GP to tailor your treatment plan effectively.

Conclusion: Comprehensive Key Takeaways

Managing RLS effectively requires a comprehensive approach, especially when medications are involved. In the UK, patients should work closely with their GP to identify medications that may exacerbate symptoms and explore alternative treatments like shockwave therapy and Therapulse devices. Practical steps include consulting healthcare providers, avoiding self-medication, and implementing lifestyle changes. By staying informed and proactive, individuals with RLS can significantly improve their quality of life and manage symptoms more effectively.

Important: This article is for informational purposes only. Always consult with qualified healthcare professionals for personalized advice.